Clonal evaluation of prostate cancer foci in biopsies with discontinuous tumor involvement by dual ERG/SPINK1 immunohistochemistry
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چکیده
منابع مشابه
Loss of PLZF Expression in Prostate Cancer by Immunohistochemistry Correlates with Tumor Aggressiveness and Metastasis
PLZF is a transcription repressor, which plays a critical role in development, spermatogenesis and oncogenesis. Down-regulation of PLZF has been found in various tumor cell lines. There has been virtually no tissue study on the expression of PLZF in prostate cancer (PCa). PCa is a heterogeneous disease, most of which are indolent and non-lethal. Currently there are no biomarkers that distinguis...
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Background: Prostate specific antigen (PSA) has been used as a screening test for the early detection of prostate cancer (PC) for many years. Although the introduction of PSA test led to a considerable increase in reported prostate cancer cases, there is still some controversy over the sensitivity and specificity of this marker in distinguishing PC patients from those with benign prostate hyper...
متن کاملInferring clonal composition from multiple tumor biopsies
Motivation. Knowledge about the clonal evolution of each tumor can inform driver-alteration discovery by pointing out initiating genetic events as well as events that contribute to the selective advantage of proliferative, and potentially drug-resistant tumor subclones. A necessary building block to the reconstruction of clonal evolution from tumor profiles is the estimation of the cellular com...
متن کاملCharacteristics of Prostate Cancers Missed by Biopsies: Evaluation of Cumulative Tumor Volume Missed According to Cancer True Prevalence
Purpose: To characterize missed prostate tumors and their cumulative volume with various biopsy regimens to determine optimal biopsy schemes. Methods: We performed 6, 12 and 18-core needle biopsies on 165 and 36-core biopsies on 47 autopsy prostates, respectively. The 6-core biopsy included 6 cores from the mid peripheral zone (MPZ), the 12-core biopsy included 6 cores from the MPZ and lateral ...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2016
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.2015.148